Hyper-activation of the stress activated protein kinase pathways may therefore be critical for motoneuron degeneration and other pathological lesions observed at E18.5.
For example, species differ in the presence or absence of sperm hyper-activation, which requires high mitochondrial activity (Cummins 2009).
Calcium, apart from activating calpains, also promotes PARP-1 hyper-activation through production of ROS and peroxynitrite [ 102].
FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells.
Mortality in septic shock was partially related to hyper-activation of NF-κB [7, 48].
Hyper-activation of STAT3 is proposed to be a predictive biomarker of trastuzumab resistance.
This accumulation is related with hyper-activation of the HPA axis, alteration of cortical monoamine content, and an induced depressive- and anxiety-like state in adult offspring.
Increased expression of T3SS related genes (such as hilA, avrA, sopE and sopC) indicates hyper-activation of T3SS in internalized isolates contributing better survival in internalized conditions.
Lop/+ lenses were further characterized by abundant TUNEL-positive nuclei within central degenerating fiber cells, glutathione depletion, free-radical overproduction, and calpain hyper-activation.
Chronic hyper-activation of the hypothalamus pituitary axis is associated with the suppression of reproductive, growth, thyroid and immune functions that may lead to various pathological states.
Protection of N-acetyl cysteine (NAC) against ROS clearly suggested the implication of ROS in hyper-activation of apoptosis and cell death.
