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Biochemically, hydrogen inhalation decreased brain caspase-3, 3-nitrotyrosine and 8-hydroxy-2-deoxyguanosine-positive cells and inflammation factors concentration.
Pathologically, tissues from rats in hydrogen inhalation group showed no significant difference compared with the control group in HE staining pictures.
Water electrolysis-derived hydrogen inhalation had neuroprotective effects on cerebral ischemia/reperfusion injury in rats with the effect of suppressing oxidative stress and inflammation, and it is a possible new hydrogen resource to electrolyze water at the bedside clinically.
To determine whether hydrogen inhalation affected hemodynamics, we monitored blood pressure and heart rate under MV.
Hydrogen inhalation therapy at a safe concentration mitigated ventilator-induced lung injury in mice.
Hydrogen inhalation demonstrated potent antioxidant and anti-inflammatory effects in a mouse ventilator-induced lung injury model.
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Previous studies investigate that hydrogen gas inhalation significantly promotes the expression of Nrf2 in septic organs including lung, liver, and kidney.
In brief, after saturation of the tissue with hydrogen following inhalation of 9% hydrogen gas in air (at 1 l min−1), the blood flow value (in ml min−1 100 g−1 tissue) was calculated from the half-life of the clearance curve obtained.
In brief, after saturation of the tissue with hydrogen following inhalation of 9% hydrogen gas in air (at 1 l min−1), the blood flow value (in ml min−1 (100 g tissue)−1) in a small region was calculated from the half-life of the clearance curve obtained.
Thus, the inhalation of hydrogen gas may be a promising therapeutic strategy to relieve brain injury in sepsis.
Studies have shown that inhalation of hydrogen gas, which acts as an antioxidant, can protect the brain against free radicals in rats with ischemia-reperfusion.
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