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Running mates can help marginally; they can hurt substantially.
Ms. Stewart's empire, which rests on essentially three pillars -- television; publishing (which includes books and magazines); and sales of Martha Stewart branded housewares, linens and other products -- could be hurt substantially if any of the pillars crumbled.
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But a prolonged slowdown in sales could substantially hurt a company that once minted profit.
But analysts say the proposal could substantially hurt their profits since prices for over-the-counter drugs are generally much lower than those charged for prescription medicines.
The government conducted a preliminary environmental assessment that concluded a longer, more comprehensive study was not needed because Mexican trucks would not substantially hurt the environment.
His current Smoke Free Movies campaign wants films that include smoking to receive R ratings, which might substantially hurt their box office receipts.
These new facts are going to hurt his position substantially, however.
Online retailer eBay has reported better-than-expected results but added that a strong dollar substantially hurt the company's results.
Google will lose out on the exclusive advertising access eBay has granted to Yahoo!, but that won't substantially hurt Google's position.
In other words, Trump is out of step with most Republicans on the war in Iraq, but he has yet to pick a fight that would substantially hurt his reputation in his party.
That referred to the shares in a company rising substantially, hurting investors who, like Mr. Ackman, are betting that the price will go down.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com