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Political insecurity and ups and downs in policy schemes have been a major hurdle for development in the past.
Subtype specificity appears to be a hallmark (and a major hurdle for development) of small molecule fusion inhibitors that target this region of the HA protein.
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Are there any serious hurdles for development of a fully functioning software?
A major hurdle for the development of LAIV exists in achieving the proper level of attenuation while maintaining immunogenicity.
The appearance of drug resistance is the main hurdle for the development of antiviral drugs [6], [7], [8], [9].
ELISA may offer optimal sensitivity; however, lack of availability of bovine specific antibodies for different proteins is one major hurdle for ELISA development.
Thus, delivery represents the main hurdle for broader development of siRNA therapeutics.
The treatment of brain pathology is the main goal and hurdle for the development of a therapeutic approach for MPS-IIIA.
Currently, the biggest hurdle for the development of pharmacometrics in Africa is the lack of a local network of centers of excellence fostering an African community.
The show has made tremendous contributions in promoting openness, transparency and freedom of speech in the region, but hurdles remain for development of the type of policy change that came from glasnost and perestroika in the former Soviet Union in the 1980s.
This poses a significant hurdle for AO drug development as drug developers will be unable to validate the efficacy of AO targeting human dystrophin exon in animal models, which is generally considered to be essential for regulatory approval of clinic trials.
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