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If regulators of HML-2 transcription were differentially expressed in humans expression levels of those regulators could indirectly result in differential HML-2 expression levels.
In humans, expression of the phage encoded leukocidin PVL is associated with increased severity of infection35,36,37.
MalarImDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice.
Consistent with our findings in humans, expression of BRAF-V600E in BM DC progenitors recapitulated many features of the human high-risk LCH, whereas BRAF-V600E expression in differentiated DCs more closely resembled low-risk LCH.
IL-17 expression may be completely extinguished such that Th-17 cells develop a Th-1 phenotype, though in humans, expression of the Th-17 marker CD161 is maintained on these "converted" cells [40].
In humans, expression of CENP-A peaks in G2 phase [5] and it has been demonstrated that newly synthesized CENP-A is incorporated at centromeres in a discrete window in G1 [12] Fission yeast centromeres resemble those of vertebrates in that the kinetochore domain is found embedded in pericentric heterochromatin.
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