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Human lymphocytes in humanized mice were derived using stem cells from 5 different human donors, and isolated from humanized mice spleen 3 days after irradiation.
Representative flow cytometry plots show the engraftment of human cells in non-irradiated humanized mice and hematopoietic reconstitution with human T and B cells in humanized mice.
Statistical analysis of the proteome from human lymphocytes, isolated from humanized mice 3 days after irradiation.
Radiation-induced changes in candidate protein expression in human lymphocytes isolated from humanized mice.
Wheeler, L. A. et al. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.
Wang, C. et al. Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice.
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Overall, movement is greatest for humanized mice, and least for aged, non-humanized mice.
Wounded gene-targeted skin-humanized mice re-capitulated native skin wound-healing features.
Thus, M2C PrPSc lacked infectivity to the PrP-humanized mice.
These transmission experiments revealed that M2C PrPSc lacked infectivity to the PrP-humanized mice.
Intracerebral transmission to PrP-humanized mice was performed using 20 μl of the homogenates [ 15].
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