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Skeletal muscle data used in the meta-analysis was generated from mouse, rat, and human tissues, providing evidence that the results are consistent across species and platforms.
Both point-scanning and line-scanning confocal microscopes have proven successful for imaging of human tissues, providing resolution and optical sectioning to observe nuclear and cellular detail.
Finally, as well as its implications for the maintenance of the human airway epithelium, this study provides a benchmark to show how clones derived from the acquisition of somatic mutations can be used quantitatively to explore the pattern of homeostatic growth in other human tissues, providing a platform to investigate factors leading to dysregulation and disease.
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Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts.
More precisely, in the second source, expression data were retrieved and compared for the replicates of 79 physiological human tissues, provided by Su et al., 2004 [ 36].
Mis-splicing has been implicated in numerous human diseases [ 2- 4] and therefore knowing the alternative splicing landscape of human tissue provides a starting point for evaluating splicing events as diagnostic markers for disease.
In the current FANTOM5 project, a modified protocol of CAGE for high-throughput single molecule next-generation sequencing with Helicos (hCAGE) has been applied to a wide range of human and mouse tissues providing an unprecedented dataset for promoter usage analysis [ 11].
We are grateful for the human brain tissues provided by National NeuroAIDS Tissue Consortium including California NeuroAIDS Tissue Network, Texas Respiratory for AIDS Neuropathogenesis Research, University of California, Los Angeles and The Manhattan HIV Brain Bank.
We acknowledge use of human aortic tissues provided by the National Disease Research Interchange (NDRI), with support from NIH grant 5 U42 RR006042-20.
The human reproductive tissues provide an extremely interesting source of stem cells from both the basic and clinical views, which are more natural than iPS cells and also avoid several dilemma related to human embryonic stem cells.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1755-8794/5/25/prepub We acknowledge use of human aortic tissues provided by the National Disease Research Interchange (NDRI), with support from NIH grant 5 U42 RR006042-20.
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