Sentence examples for human telomere base from inspiring English sources

The human telomere base sequence (Tel-22) prepared in Na+ buffer forms a G-quadruplex structure with the characteristic CD spectrum shown in Figure 1A.

In cells, the predominant G-quadruplex structure for the natural human telomere sequence is proposed to be the hybrid fold, based on the K+ concentration inside the cell and its binding affinity for the G-quadruplex.

The DNA alkylating activities of conjugates 5 7 were evaluated by high-resolution denaturing polyacrylamide gel electrophoresis with a 219 base pair (bp) DNA fragment containing the human telomere repeat sequence.

Here, we synthesized three types of Py Im polyamides 1 3 based on TH59 for specific recognition of human telomere repeat sequences.

Instead, the base pairing of 2-amino-Adap with dG was significantly destabilized compared with that of Adap with dG, resulting in improved selectivity for 8-oxo-dG in the human telomere DNA sequence.

This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of 5′-dG3 TTAG3 3 5′-dG3 TTAG3 3druplex-forming unithef the human telomere DNA.

Here we report that human telomere guanine-rich sequence AGGG TTAGGG 3 (G4) and hemin can form a G-quadruplex hemin complex (G-quadruplex hemins good elecomplexmical characteristics.

These studies may provide a new way to characterize the structure and properties of human telomere and may have further applications.

We designed and synthesized human telomere alkylating N-methylpyrrole-N-methylimidazole (PI) polyamide conjugates (1 6).

NMR and X-ray crystallography have demonstrated that human telomere RNA forms G-quadruplex structures.

In this study, using the click chemistry we successfully found that a 6-mer human telomere RNA and 16-mer human telomere DNA sequence can form a DNA RNA hybrid type G-quadruplex structure.