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Indeed, Misty has become a testament to the Elephant Sanctuary's signature ''passive control'' system, a therapy tailored in many ways along the lines of those used to treat human sufferers of post-traumatic stress disorder.
The mouse "model" of the human version of Alzheimer's disease is imperfect not least because the animals fail to show many symptoms found in human sufferers, such as nerve-cell death, confusion and immobility.
But the results are so extraordinary that they should give hope to human sufferers.Dr Courtine paralysed his rats by cutting their spinal cords in two places, so that the animals could no longer move their hind legs.
These mice have their hemoglobin genes removed and replaced with the mutated human version, saddling them with many of the same problems as human sufferers, including immature, short-lived, and sickle-shaped red blood cells; anemia; reduced blood flow; and an enlarged spleen.
Corrected cells programmed to produce normal neutrophils can theoretically be reintroduced into human sufferers with the same results.
One must remember that the mdx mouse is relatively healthy in comparison with human sufferers of DMD.
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In the same interview, he claimed that disease was not only physically debilitating but psychologically degrading: "physical wretchedness has done its worse on the human sufferer, for it has destroyed his mind... [it] annihilates the mental faculties the faculties distinctive of the human being".
Having redefined executioners as heroic sufferers and having stifled his empathy for human suffering, including his own, Eichmann was numb enough to follow his new conscience.
Salivary glands are present in HED mice, though their embryonic development is poor [40], and these glands are also present in human HED sufferers, though they produce less saliva than normal and the saliva produced has an altered chemical composition [41].
In terms of species differences, one important difference in the development of the mdx mouse compared with human DMD sufferers is that skeletal muscle tissue in the mouse undergoes a wave of necrosis followed by recovery at 2-3 months.
This process seems to be mediated via a histone deacetylase, HDAC2, which the authors have shown to be activated in brain tissue from both transgenic mouse models, where it reduced synaptic density and memory function, and human AD sufferers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com