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Despite a dearth of human studies, available data suggest that pesticides in our food indeed pose a risk.
There are only a few small-scale human studies available.
In addition to the available non-human studies, the human studies available so far focussed mainly on fragments of the longitudinal chain pregnancy - early life - childhood.
Most of the human studies available focus on the physiological effects of fluid boluses [ 3- 5] rather than on patient-centered outcomes.
For example, a suggested mechanism of action for arsenic is through epigenetic dysregulation, although there are limited human studies available (Ren et al. 2011).
However, the limited number of human studies available, and the inconsistencies among them, warrants the need for well-controlled human studies with respect to exposure assessment and subject-matching between the exposed and control groups.
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The NTP (2008) limited its review to those studies related to risks for human reproduction; most of the human exposure studies available at the time were included in the assessment, whereas only a portion of the animal literature was considered useful.
In reaching these conclusions, vom Saal et al. (2007) examined the entire body of scientific data (Crain et al. 2007; Keri et al. 2007; Richter et al. 2007; Vandenberg et al. 2007; Wetherill et al. 2007), including > 40 human biomonitoring studies available at the time and the two human toxicokinetic studies.
No controlled human studies are available.
The search was performed without limitations by species although subsequent priority was given to human studies, where available.
In contrast to the animal and in vitro findings, there are limited human population studies available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com