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The chimerism of human-mouse lung was further confirmed by human-specific nucleus antigen Lamin A+C co-staining with GFP (Fig. 3B) and qPCR with human specific GAPDH primers (Fig. S6A).
(D) Confocal image with human specific Lamin A+C immunostaining (HuLamin) showing regenerated type I (AQP5+) alveolar cells.
Endocan concentrations were measured using a human specific quantitative sandwich enzyme-linked immunosorbent assay (ELISA) technique (Lunginnov, Lille, France).
The differentiation potential of SOX9+ BCs was further confirmed by qPCR analysis of multiple marker genes with human specific primers.
(B) Immunofluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma with human specific Lamin A+C marker costaining.
The transplanted NPs were identified in brain sections by immunofluorescent stainings for human-specific mitochondria, human specific nuclear antigens or GFP (Fig. 3).
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In terms of disease biology, humanized mice can be used to study infection with human-specific pathogens, human autoimmune diseases, and human-specific immune responses in many contexts.
"I think it is human-specific," Dr. Karch said.
Genes that seem to play a role in speech are obvious places to look for human-specific changes.
Is there a human-specific smell of death?
Researchers already knew that overimitation was a human-specific quirk.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com