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Fibroblast growth factor 18 (FGF18) is one of the key factors in human signaling pathways and has been reported to be associated with the formation of various tissues.
Our study demonstrates that signaling games, which have previously been applied to economic decision-making and animal communication, provide a framework for human signaling behavior arising during sensorimotor interactions in continuous and dynamic environments.
Specifically, PID provides information about 184 different human signaling pathways.
For more general insights of disease-associated microRNAs, we analyzed their impact on human signaling pathways from two perspectives.
By targeting a subset of the human signaling proteome, we found that the catalytic subunit IKKα is also required for complete NF-κB activation during infection.
The basic idea of the randomization tests was introduced here by taking the test for the enrichment of co-occurring mutations in human signaling pathways as an example.
Steps towards these goals have been taken, e.g., by Reactome [21], where pathway curation is standardized and human signaling functions are transferred from other species.
Co-occurring mutated genes were first mapped into 183 human signaling pathways, and 42 pairs of genes with co-occurring mutations were mapped to the same pathways.
In addition, we kept all pathways that have more than one predicted microRNA target gene, leading to a final data set of 79 human signaling pathways containing 1573 unique human proteins.
By targeting a subset of the human signaling proteome, we identified IKKα as a protein required for S. flexneri-induced NF-κB nuclear translocation and IL-8 secretion in HeLa cells.
An in vitro diced siRNA library targeting 132 genes from the human signaling proteome was screened on S. flexneri-induced p65 nuclear translocation as described in Materials and Methods.
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