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Human soluble calcium-activated nucleotidase (human SCAN) is a homologue of the salivary anti-coagulant apyrases injected by insects into their hosts to allow blood feeding.
The bed bug insect homologue of human SCAN was also expressed and purified, and used in these in vivo experiments as a benchmark to assess the therapeutic potential of the engineered human enzymes.
Thus, for the first time, we show that an engineered form of this human protein is efficacious in an in vivo model of thrombosis, demonstrating that suitably modified human SCAN enzymes have therapeutic potential as anti-coagulant and anti-thrombotic therapeutic agents.
In a real human scan, MR k-space data used for motion estimation for a given motion phase are acquired only when the motion phase is reached.
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By site-directed mutagenesis, two mutant human SCANs were constructed and expressed in bacteria.
Additional file 1: Details on the analysis on pigs and human scans.
Third, human scans were collected retrospectively, with poor control on the acquisition parameters.
We anticipate that some of these aspects are manageable or even non-existent in future human scans.
Data are retained by the authors as both animal and human scans are also included in two unrelated studies.
The position of the color target varied considerably as the human scanning operator was allowed to put the color target anywhere in the vicinity of the item to digitize.
Aftab says that this system is effective, but I don't regard it as "aggressive" – I'd much rather hear that Facebook employs a dedicated team to scan through photos, even if only for those shared by minors (or even better, a combination of flagging and human scanning).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com