Sentence examples for human risk based from inspiring English sources

We subsequently incorporated this information into the EVD model and threshold human risk based on known human cases instead.

Subsequently, due to retrospective and prospective case reports of neural tube defects in humans with first-trimester exposure to efavirenz, the FDA reclassified the drug as class D (there is positive evidence of human fetal risk based on studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks).

The FDA classifies category X drugs in pregnancy as medications where studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

The problem of quantitatively estimating human cancer risk based upon animal carcinogenesis studies is reviewed.

Conolly et al. (2004) claimed to provide conservative estimates of human risk, and based on the model it was concluded that cancer risks associated with inhaled formaldehyde are de minimis ≤ 10−6) at relevant human exposure levels.

Efforts should be placed on deciphering the dose response relationship in rodent studies and applying it to human risk assessment based upon PBPK models that account for metabolite deconjugation in conjunction with other pharmacokinetic factors.

Women were excluded if they had also filled a prescription for a category X drug, defined as a medication where studies in animals or humans have demonstrated fetal abnormalities or where there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit [ 22].

An important limiting factor in assessing risk based on human studies is the degree of measurement error associated with the exposure estimate(s) used in a particular study.

1,3-butadiene is also considered by the EPA to be a known human carcinogen, with an inhalation unit risk based on epidemiological evidence.

Risk based approach of PSM calls for addressing the potential technical, human, and organizational failures simultaneously.

All are at risk based on the current and projected habitat loss or destruction due to human encroachment and climate change.