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In vitro cytotoxicity assays revealed that SQdFdC was more active than dFdC on a transporter-deficient human resistant leukemia model, which was explained by the subcellular distribution of the drugs and their metabolites.
Using a human resistant pancreatic cell line [ 9], we demonstrated that PLGem promoted more cytotoxicity and apoptosis than both GemPo and free Gemcitabine, which translated into strikingly different mechanisms of action at the ultrastructural level.
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Moreover, inactivation of the gene CMAH in the human lineage blocked conversion of the sialic acid N-acetylneuraminic acid (5Ac) to N-glycolylneuraminic acid (Neu5Gc), making humans resistant to P. reichenowi.
In healthy humans, resistant starch decreased faecal phenol and ammonia [ 74].
If engineers would design an acoustic signal for communication among humans, resistant to all kinds of acoustic interferences, they would probably not come up with something resembling natural speech.
Similar to the situation in humans, resistant viruses in waterfowl are likely to be cleared or revert to wild-type once river OC levels fall and the selection pressure is removed.
HS, susceptible isolates from humans; HR, resistant isolates from humans.
Using antibiotics in animals raises concerns of spurring development of human pathogens resistant to the medicines.
Porcella, A., Maxia, C., Gessa, G. L. & Pani, L. The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies.
Importantly, single-copy expression of this construct rendered transduced target cells, including primary human macrophages, resistant to infection with a CCR5-tropic strain of HIV.
Tumor bits 20-300 mm) of human castration resistant prostate tumor xenograft LuCaP 35V were implanted subcutaneously.
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CEO of Professional Science Editing for Scientists @ prosciediting.com