Sentence examples for human residue from inspiring English sources
When the amino acid in the human POLG sequence was different from the corresponding residue in yeast Mip1p, in addition to the allele with the wild-type yeast residue replaced with the mutated human POLG amino acid (putative pathological allele), a second strain was created, with the wild-type human residue introduced into the yeast sequence, resulting in the humanized allele.
Three other were conserved in terms of amino acid features (i. e. polarity, hydrophobicity) but distinct from human residue and variable among rodents (R263K, K360R and K434R).
Models are represented as poly-alanine but labeled according to the predicted human residue number, except for the helical bundle, which is entirely poly-alanine.
The human and yeast constructs used in this study are truncated at similar points relative to the motor domain (human residue number 1284 and yeast residue number 1219) and fused to GST.
Guided by sequence and lineage analysis of a panel of neutralizing RabMAbs, we humanized the lead candidate by substituting non-critical residues with human residues within both the frameworks and the CDR regions.
Second, a set of framework residues that appeared to be on the surface of several selected human antibodies was identified and human residues at those positions were chosen to be introduced in the V5B2.
The introduction of human residues at selected positions in the murine model of V5B2 has not revealed major disturbances in the conformation of CDRs, so the third version of humanized scFv V5B2, LLHmut3, was designed.
They are embedded in a 78-residue sequence spanning avian residues 3208 3285 (corresponding to human residues 3260 3337).
The mutant NTCPs include hNTCP-bearing mutations of mkNTCP residues and mkNTCP-bearing mutations of human residues at indicated positions.
Sherer et al. substituted human residues into murine Crm1 to determine which residues enhanced virus-like particle production (Sherer et al., 2011 ).
HepG2 cells were transfected with plasmids encoding hNTCP, mkNTCP, or hNTCP variants bearing the indicated monkey residues, or mkNTCP variants with the indicated human residues.
