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The interventional studies for human recurrence have serious flaws, particularly in lacking a real control group generated by a randomization and in using combined interventions that do not allow for isolating the effects of folic acid [ 120].
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The comparison of different civilizations or of successive periods of order and disorder in Chinese or in pharaonic Egyptian history implied, of course, that, in human affairs, recurrence is a reality.
In clinical studies, the abundance of stromal myofibroblasts predicts human disease recurrence.
Intriguingly, the risk of human HCC recurrence is positively correlated with Cirp expression in liver.
Due to the different genetic mechanisms by which soluble neurexin products arise in the bee and humans, the recurrence of this phenotype may be a case of convergent evolution.
These recurrent tumors exhibit epithelial-mesenchymal transition (EMT), which seems to be mediated by the upregulated expression of the transcriptional repressor Snail, a molecular process that seems to have a high prognostic value in predicting human breast cancer recurrence.
High levels of JAG1 are correlated with a more aggressive disease course and recurrence in human prostate cancers (Santagata et al, 2004) and indeed, a metastatic human prostate cancer cell line (PC-3 cells) expressed high levels of JAG1 protein.
This study provides a striking example of how accurate mouse models can provide insights on molecular processes involved in progression and recurrence of human cancer.
Similarly, lactate levels predict likelihood of metastasis and tumor recurrence in human cervical cancers [ 225].
Since late 2006, however, Viet Nam has faced two other waves of outbreaks and a recurrence of human cases.
Moreover, high expression of Skp2 is correlated with tumour recurrence in human cancers (Einama et al, 2006).
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