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In her Catalysis performances (1970), Piper turned herself into a human provocation in public places such as the New York subway.
Human provocation studies of migraine using systemic administration of different molecules have generated important insights into the possible mechanisms in primary headache diseases.
For future human provocation studies, it would be interesting to measure PACAP38 plasma levels after sumatriptan administration when using PACAP38 or other pharmacological "triggers" such as CGRP and cilostazol.
It should, however, be noted that two human provocation studies collected peripheral plasma levels of inflammatory mast cell mediators (tumor necrosis factor alpha and tryptase) in MO patients after PACAP38 infusion [34, 43].
In the context of human provocation studies, subcutaneous injection of sumatriptan caused co-occurring MMA constriction and amelioration of migraine-like attacks following both PACAP38 [33] and CGRP [40] infusion.
It is also this combination of human provocation (aka Martin "interviewing" Marissa Mayer!) and data abundance that makes Stream such a powerful gathering.
Similar(52)
This situation has dramatically changed over the last couple of decades, not least as a consequence of the increasing use of a human migraine provocation model that demonstrates the importance of naturally occurring signaling molecules in migraine.
We did not directly compare the brain response to "unseen" sexual vs. cocaine cue categories because of the difficulty – for human cue-provocation studies – in equating the cues on a critical dimension: their relevance for the individuals' unique learning history.
Upstairs in White Cube's Mayfair space, under a spotlight in a darkened room, was the latest Hirst provocation: a human skull covered with 8,601 diamonds.
Harsher suspensions are surely unneeded in principle to fix a bright line, and the bans fail to come to grips with the reality that the players in this incident reacted as human beings under extreme provocation to which they indisputably should not have been exposed.
We examine the intertwined nature of the actions of endotoxin and fungal components, sphingolipid biology in PKD, the structure of PKD gene products, infections, and integrity of gut function to establish a mechanistic hypothesis for microbial provocation of human cystic disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com