CREB3L4 (also called AIbZIP, Tisp40, or ATCE1) is expressed in human prostate tissue, and Creb3l4 disruption resulted in abnormal epididymal sperm nuclei, ER stress, and activation of caspase 12, leading to apoptosis of meiotic/postmeiotic germ cells.
Previously it was shown that PTK6 is localized to epithelial cell nuclei in normal prostate, but becomes cytoplasmic in human prostate tumors.
In androgen-sensitive and TGF-β-responsive human prostate cancer cells, TGF-β treatment promoted PHB1 export from the nucleus to the cytosol, which preceded apoptotic cell death [ 51].
Androgens are classically acting in androgen-receptor positive tissues, like the human prostate, as selective transcription factors, after binding to specific intracellular receptors, translocation to the nucleus and transcription of androgen related genes, as the prostate specific antigen (PSA).
Generation of human prostate organoids.
An orthotopic murine model of human prostate cancer metastasis.
P.T. and W.L. provided the human prostate cancer tissue sections.
Taylor, B.S. et al. Integrative genomic profiling of human prostate cancer.
Ellwood-Yen, K. et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors.
Human prostate adenocarcinoma PC-3 cells, human prostate carcinoma LnCaP and DU145 cells, and human normal prostate stroma/fibroblast WPMY-1 cells were obtained from the American Type Culture Collection (ATCC) and cultured as previously described22.
Conversely, the human prostate gland is a single organ.
