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For the particular case of C="1 a human proof of the conjecture exists; for C= 2 a bespoke computer program had generated sequences of length 1124 of discrepancy 2, but the status of the conjecture remained open even for such a small bound.
If the other side's point of view is something as clear as "Families are being hurt by this policy," and the best response you can muster is, "It's complicated" without any human proof points, then you've got some work to do.
'There's human proof and economic proof that people succeed in this program".
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Implanted brain computer interfaces (iBCIs) have made impressive advances since the first human proof-of-concept demonstrations.
To support and manage this anticipated breadth of clinical studies, we are building a sophisticated, highly integrated early development engine designed to deliver the highest quality mRNA drugs from candidate nomination through to human proof-of-concept (PoC) data.
Important changes in the research process are needed to allow efficient translation of preclinical discoveries to the clinic, including improvements in the laboratory and publication practices involving animal research and early incorporation of human proof-of-concept studies to optimize the interpretation of animal data for its predictive value for humans and the design of clinical trials.
Human proof-of-concept studies using CAT-354 are required to confirm these animal findings.
The fact that this barnacle of electronics is attached, parasitically, to one of the most secure and human-proof devices in existence is an amazing feat.
Since the first demonstration of GLP-1 receptor cloning and functional expression 20 years ago, enormous research efforts have been focused on developing GLP-1 receptor agonists to treat diabetes, resulting in first-in-human proof-of-concept studies in the early 2000s.
Is self-assembly of the human body proof that God exists?
Demonstration of existence, timing, and duration of target pathophysiology affected by candidate intervention in human disease (proof of mechanism).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com