Sentence examples for human progenitor cells from inspiring English sources
Investigators have demonstrated the expression of introduced TCRs following differentiation of human progenitor cells on mouse stromal cell lines expressing the Delta-like 1 molecule [15], [16].
We performed two types of in vivo assays, one reconstituting mouse bone marrow with mBM-VPC with altered expression of Dll4 and the other introducing exogenous human progenitor cells expressing Dll4.
Recently, two studies demonstrated that CD34+ human progenitor cells isolated from either umbilical cord blood (CB) or fetal liver could be injected into irradiated Rag2-/-γc-/ newborn mice resulting in the development of a human immune system (HIS [4], [5].
It is remarkable that given the severely degenerative xenograft environment, the human progenitor cells were still able to survive, integrate and release GDNF that had a protective effect on motor neurons in this model of familial ALS.
The arrest of growth factor-induced G1/S transition protects murine and human progenitor cells from the toxicity of the cell cycle-dependent anticancer drug Ara-C in vitro and reduces aplasia in a murine model of chemotherapy.
For example, mouse and human progenitor cells and induced pluripotent stem cells can be maintained in a self-renewal state by growth on a layer of 'feeder' fibroblast cells and similar techniques could be adapted for C. elegans larva cell culture [59], [62].
This system has been shown to support T lineage differentiation from a variety of mouse and human progenitor cell sources [18], [29], [30].
Moreover, BMPs are required for human progenitor cell commitment to the endothelial lineage.
Among the HSCs and HPCs, EPCs are the most widely studied adult human progenitor cell subpopulation up to now.
Thus, EZH2 levels determine the higher-order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control.
However, during the antibiotin incubation step, an additional 50 μL/ml human hematopoietic progenitor enrichment antibody cocktail from the StemSep Human Progenitor Cell Enrichment Kit was added to deplete human-lineage-positive cells.
