Exact(3)
However, the roles of miRNAs/p21WAF1/CIP1 in the DDP resistance of human LAs are unclear.
Our findings shed novel light on the roles of miR-224/p21WAF1/CIP1 signalling in the DDP resistance of LA cells, and targeting it will be a potential strategic approach for reversing the DDP resistance in human LAs.
Thus, this report identifies novel signalling pathways and molecules as potential therapeutic targets for the treatment of DDP-resistant human LAs.
Similar(57)
Among the host factors controlling HCV replication or translation in trans, several candidates are involved in mediating both of these processes, including human La protein, poly rC -binding poly rC -binding) and mice minute virus NS1-associated protein 1 (NSAP1) (Ali et al., 2000; Ito and Lai, 1997; Chang and Luo, 2006; Spangberg and Schwartz, 1999; Park et al., 2011).
The worst emotions you can have on this hamster wheel we call life resonate with his flair for grotesqueries: a human La-Z-Boy is a weekend Netflix and chilling alone; an escalator into to a digestive tract is your daily commute.
The worst emotions you can have on this hamster wheel we call life resonate with his flair for grotesqueries: a human La-Z-Boy is a weekend Netflix & chilling alone; an escalator into to a digestive tract is your daily commute.
Human La has been found to function as a dimer.
Human La autoantigen is a dimer and contains several RNA binding domains [24].
Extensive analysis has been done to understand the mechanism of human La function in IRES mediated translation.
Fig. 1C shows the structure of the human La RRM1 with the conserved residues mutated in RNP1.3 highlighted (VVF).
Human La contains a classical NLS and is imported into the nucleus via the Kap α/β heterodimer [4], [13].
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