Roberts, J. E., Kukielczak, B. M., Chignell, C. F., Sik, B. H., Hu, D. N. & Principato, M. A. Simulated microgravity induced damage in human retinal pigment epithelial cells.
Both assemblies induced damage to human neuronal cells and mature rat hippocampal neurons, and these Aβ species were assigned a role in disturbing presynaptic signaling mechanisms [ 77].
We were the first to show that LRRK2 G2019S mutation carriers have increased mitochondrial DNA (mtDNA) damage using human induced pluripotent stem cells (iPSC -derived neural cells (Sanders et al 2014).
Momcilovic O, Knobloch L, Fornsaglio J, Varum S, Easley C, Schatten G. DNA damage responses in human induced pluripotent stem cells and embryonic stem cells.
Dannenmann B, Lehle S, Hildebrand DG, Kubler A, Grondona P, Schmid V et al. High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.
The fruit extract showed its protective and chemopreventive properties in human skin fibroblasts against ultraviolet- (UVA and UVB) induced damage.
Human induced pluripotent stem cell.
Human induced soil degradation.
In contrast to FasL, the administration of which causes lethal liver failure in mice (Tanaka et al, 1997), injection of TRAIL was suggested not to reveal general toxicity (Ashkenazi et al, 1999b; Walczak et al, 1999), although it was recently shown to induce damage in human hepatocytes and normal brain tissues (Jo et al, 2000; Nitsch et al, 2000).
In contrast to fibroblast gene expression profiles, the pattern of gene modulation in normal human keratinocytes in response to I-induced damage is distinct, with only two transcripts being common for keratinocytes and any of fibroblasts tested.
The impact assessment method developed by Pfister and colleagues comprises (amongs others) two damage assessment models which describe the cause-effect chains of water consumption leading to malnutrition induced human health damage and ecosystem damage resulting from reduced net primary production (Pfister et al. 2009).
