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Human imprinting disorders are usually associated with placental abnormalities.
The study of human imprinting is more difficult than it is in animal experiments.
Nonetheless, it remains to be addressed how 5hmC is linked to the development of human imprinting disorders.
In most of the known human imprinting disorders, the biological link between the epigenetic mutation and its biological and clinical manifestation remains missing.
Stable iDMRs have been characterized for 25 human imprinting regions [ 15, 16] and where array features overlap these, we would expect monoallelic (therefore 50% (β=0.5)) methylation.
In conclusion, homozygous and compound-heterozygous mutations in ZFP57 cause a human imprinting syndrome as yet only ascertained through presentation with TNDM1.
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* p < 0.1, ** p < 0.05, *** p < 0.001 (χ2 or Wilcoxon test for comparison of the respective imprinted group to autosomal data) Compared to genome-wide data, human imprinted genes show less identity with their most recent paralogs on protein level (p < 0.06, Table 3).
The human imprint is evident almost everywhere.
Rainier is a sanctuary, a living museum of the land without much of a human imprint.
In an interview, Dr. Delgado of the ocean agency said the muddy seabed showed "clear signs" of human imprint.
The human imprint is heavy on the landscape and is particularly evident in the absence of trees.
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