Sentence examples for human frameworks from inspiring English sources
The six CDRs of B233 were fused in-frame to pools of corresponding individual human frameworks.
These human frameworks encompassed all known heavy and light chain human germline genes.
Precise control over design enables the use of highly optimized human frameworks and the introduction of defined chemical diversity at positions that are most likely to contribute to antigen recognition.
Humanization of 3D6 was effected by a combination of CDR grafting of mouse residues from 3D6 VL and VH into human frameworks, and homology model guided retention of select mouse framework residues in the initial humanized version of the monoclonal antibody (mAb) [ 31, 32, 35, 44, 45].
By cloning the hypervariable domains of a mouse antibody specific for human DC-SIGN into human framework regions, we obtained a humanized antibody.
HFA consists of two steps: human framework selection (HFS) and specificity-determining residue optimization (SDRO).
A chimeric version of anti-CD40L Fab was generated by transferring mouse variable regions into a human framework.
It contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions.
The synthetic phage antibody library described here utilizes a single human framework with a template containing human consensus complementarity-determining regions (CDRs).
Humanization of a potent neutralizing mouse anti-human IL-13 antibody (m836) using a method called human framework adaptation (HFA) is reported.
Phage-displayed synthetic antibody libraries were built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions (CDRs).
