Sentence examples for human framework from inspiring English sources

By cloning the hypervariable domains of a mouse antibody specific for human DC-SIGN into human framework regions, we obtained a humanized antibody.

Thus, without requiring any rational design or structural information, this new humanization approach allows to rapidly identify various human framework combinations able to support the structural feature(s) of the CDRs which are essential for binding and functional activity.

HFA consists of two steps: human framework selection (HFS) and specificity-determining residue optimization (SDRO).

A chimeric version of anti-CD40L Fab was generated by transferring mouse variable regions into a human framework.

Phage-displayed synthetic antibody libraries were built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions (CDRs).

Simple grafting of six CDRs of the chicken antibody into a homologous human framework (FR) template resulted in the complete loss of pT231-peptide binding.

These human frameworks encompassed all known heavy and light chain human germline genes.

The six CDRs of B233 were fused in-frame to pools of corresponding individual human frameworks.

Other systems were studied with similar results, including the tumor suppression p53 within a mouse-wolf(dog -human framework, leadog -humannew hypothesis oframeworkng the bovine PKM2 pathways for targeting the gleadingis preference in many topes of canewrous cells, thypothesismenting quantum metabofincludinges as well.

The CDRs of cetuximab heavy and light chains were grafted onto human antibody frameworks as framework donors.

To design a humanized antibody, we graft the mature murine CDRs onto a germline human acceptor framework.