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And, finally, they feel human, fragile, cultural connective tissue.
One such gene is the human fragile X mental retardation 1 (FMR1) gene.
Table 1 demonstrates this complicated relationship in human Fragile X Premutation and Full Mutation carriers.
A sample report is shown in Figure 4 for the RGG box and flanking sequence of the human fragile X mental retardation 1 (FMR1) protein.
The two most commonly expressed human fragile sites, FRA3B and FRA16D, harbor genes which have a tumor suppressive function, namely the fragile histidine triad, FHIT, and the WW domain containing oxidoreductase, WWOX genes respectively [ 1- 3].
Although these results were replicated in Fmr1 mutant mice (Dolen et al., 2007; Yan et al., 2005), clinical trials for mGluR antagonists failed to demonstrate sufficient efficacy for some behavioural parameters in human fragile X patients (Jacquemont et al., 2011).
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The conservation implications are for humans: fragile and dependent organisms".
FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human common fragile sites, where FHIT lays.
"All of you who watch these shows, don't forget that these are real people you're watching, as real and human and fragile as you are -- and as deserving of respect".
In Synecdoche, New York, Kaufman creates the imaginative equivalent of a basic component of human life, fragile, ever changing in shape, elusive and contradictory in its instinct both for creation and extinction.
Sequence analyses of the human common fragile sites, however, revealed no cis-acting sequences that can explain their instability [30] [33].
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