The full genomic sequence of DA/O, DA/K, E3 and PVG constitutes an invaluable resource in the understanding of how polymorphisms in the DA genome contribute to disease susceptibility and this genetic blueprint of an inflammation permissive rat strain will also be important in the understanding of the human etiologies for chronic inflammatory disease.
Her research focuses on the role of mitochondria in the maternal and cross-generational toxicity of polycyclic aromatic hydrocarbons, with important applications in organismal ecological fitness and insights into human disease etiology.
Obesity, reflecting that of human dietary etiology, was induced with a cafeteria-style diet (∼30 kJ, fat) over 16 20 weeks.
We have initiated studies in Drosophila to examine the tissue-specific roles of A-type lamin with implications for understanding human disease etiology.
Both nurture (environmental) and nature (genetic factors) play an important role in human disease etiology.
Our results will contribute as a resource for future chromosomal translocation studies, particularly, for studying their roles in human disease etiology and mechanisms.
Crossing the Rac-FRET mouse to various models of disease has demonstrated its utility for assessing the effects of mutations that recapitulate human disease etiology on Rac activity in a time- and tissue-specific manner, even in organs and tissues that contain complex mixtures of cell types, without affecting tissue homeostasis.
An ideal animal model should recapitulate the disease in humans in etiology, pathogenesis, and molecular features.
Such insights from evolutionary biology are based on integration of two large research areas, the evolution of humans and the etiology of human neurogenetic conditions, that have thus far developed in considerable isolation.
Of equal importance, there is a great potential of differences between the hapten-induced model of AD used here and human AD, the etiology of which is still incompletely understood and might include many additional factors, such as inherited barrier dysfunctions [13, 15, 16, 31, 37].
