From his work in "This Is Spinal Tap," directed by Rob Reiner, to the films Guest has made on his own, including "Waiting for Guffman" and "A Mighty Wind," he has crafted an ongoing, warmhearted celebration of human enthusiasms and failures.
"The Great British Take the Bins Out?" "The Great British Pull the Hair Out of the Plughole?" "The Great British Cat Turd Clean-up?" I like the sound of them all, but perhaps I've been brainwashed by the super-human enthusiasm of GBGR's presenting team.
In the absence of information on the relation of CVD risk to CETP activity in humans, enthusiasm for the concept was fuelled by positive results in cholesterol-fed rabbits, which seemed to confirm that a rise in HDL cholesterol is a dependable biomarker of benefit.
Although potently immunogenic, the efficacy of vaccines based on HAdV-C5 appears hampered by high seroprevalence rates in humans, and enthusiasm for their use as clinical vaccine platforms has been dampened by the well-publicised failure of the MERCK sponsored STEP vaccine trial.
But extra money to teachers is a bargain if New York City can unleash human energy and enthusiasm in its schools.
A new technology is allowing surveillance cameras to detect suspicious activity without human supervision, prompting enthusiasm at security and counterterrorism agencies and outrage among "Big Brother" opponents.
Such a spectacle seems torn from the feeble imaginings of some bygone science-fiction author: a doomy vision in which humanity – having lost all enthusiasm for human interaction – resolves to consume the splendours of the Earth exclusively through cinema screens.
He's scanning the horizon, coolly indulging one of his ardent enthusiasms: human flight.
Even before yesterday's murders, there had been worrying signs of Tunisians' fading enthusiasm for human rights.
The Bush administration's enthusiasm for human rights would be more believable if it were less selectively applied.
