Sentence examples for human efficacy from inspiring English sources
A big part of the problem is that animal models are not particularly predictive of human efficacy".
"We've been stymied for some products figuring out a way to show human efficacy, given the ethical issues," said Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the F.D.A. "One of the reasons there wasn't commercial interest was that people were not at all certain their drugs could be approved if they developed them".
We conclude that protein-based PfRH5 vaccines are an urgent priority for human efficacy trials.
A hundred experimental drugs are now in human efficacy trials, targeted at crucial "lethality" genes that help some tumors spread and kill.
The search for an HIV-1/AIDS vaccine will only succeed through the conduct of well-designed, well-conducted and well-controlled human efficacy studies.
Musk said that current Tesla vehicle computer and sensor hardware would allow for "roughly human-level autonomy," but also noted that regulators might require a higher level, with potentially systems needing many multiples of human efficacy to be deemed legal to operate.
However, additional studies are required in models that can capture pathogenesis seen in humans, efficacy in aged populations, and possibility of immune pathology due to heterologous challenge.
There is ample evidence that mice may not be reliably used to predict human vaccine efficacy.
During anti-arrhythmic drug (AAD) development, establishing human drug efficacy in phase I to III studies is often hindered by problems of proarrhythmia and tolerability.
The two kinase inhibitors that have moved farthest into clinical development - tofacitinib, a JAK kinase inhibitor, and fostamatinib, a Syk kinase inhibitor - have successfully bridged the gap between animal models and human clinical efficacy.
Recent findings from clinical trials have indicated that self-reactive antibodies can also be readily induced in humans; therapeutic efficacy, however, has not always been achieved.
