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Within our data set of 184 human duplicate pairs, 11.4 % (21/184) were identified as putative retrotransposed gene duplicates.
Since human duplicate genes have been shown to diverge rapidly in their spatial expression [ 23], it has been proposed that the different copies of AZFc genes vary in terms of functional properties [ 12, 16].
The large fraction of complete duplicates within our data set begs the question as to how the majority of newly minted human duplicate genes are able to rapidly assume unique species-specific functions.
We further investigated whether the relative frequencies of intrachromosomal vs. interchromosomal duplicates was altered with increasing evolutionary age by classifying the human duplicate pairs into three evolutionary age-cohorts (K S = 0, 0 < K S ≤ 0.025, and 0.025 < K S ≤ 0.1).
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In addition, human duplicates have, on average, much larger duplication spans which are more likely to capture entire ORFs leading to complete duplicates compared to higher proportions of structurally heterogeneous duplicates (partial and chimeric duplications) in Drosophila and C. elegans.
aWe quantified triads depending on brain expression status of a pair of human duplicated genes mapped to unique fly ortholog, depending on timing of duplication ("b" denotes PBE, "nb" denotes lack thereof).
We categorized the duplicated enhancers into those, with duplicated copies only in fish lineage (only a single counterpart in human), duplicated copies only in human (only a single counterpart in fish), and the ones that contains duplicated copies in both fish and human lineages.
New research credits them with yet another ability once thought to be exclusively human: duplicating the facial expressions of others.
Some families of human duplicated genes have single known ancestral orthologs, which were only counted once.
Following the methods of [ 12], we obtained a list of human duplicated genes created by WGD inferred by [ 28].
The low divergence of these human paralogues, compared with the divergence between chimpanzee and human orthologues, argues strongly that chimpanzee lacks single orthologues of many, if not all, of these human duplicated genes.
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