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When all other effects of Wolbachia on the mosquito physiology are ignored, cytoplasmic incompatibility alone results in a reduction in the number of human dengue cases.
We found that a significant reduction in human dengue cases can be obtained provided that Wolbachia-carrying mosquitoes persist when competing with mosquitoes without Wolbachia.
This study focuses on the development of a mathematical model to quantify the effect on human dengue cases of introducing Wolbachia into the mosquito population.
Moreover, Coxsackie A virus (Rieder et al. 2001) and sylvatic dengue virus (Vasilakis et al. 2011) could potentially emerge to fill the niches left vacant should polio and human dengue virus, respectively, be eradicated.
These data indicate that several infected engrafted mice exhibited clinical features of human dengue illness although these features were not consistently observed.
The ELISA results showed that the human dengue serum reacted with eleven peptides along the entire length of the E-glycoprotein molecule.
Similar(35)
Existence of several closely related flaviviruses in the American tropics (8 – 10 ) may convey cross-protection in animals (e.g., ILHV and SLEV) or humans (dengue viruses, yellow fever virus), thereby potentially diminishing disease caused by a newly introduced flavivirus such as WNV.
Synthetic disease refractory genes have already been developed for human malaria, dengue fever and avian malaria [ 2- 5].
A key goal in developing the model has been to capture the most important features of mosquito population dynamics, relevant human behaviour, dengue transmission and control without making the model overly and unnecessarily complex.
In addition, historically established infectious diseases, such as West Nile fever, human monkeypox, dengue, tuberculosis, and malaria have reemerged or resurged, sometimes in populations that previously had been relatively exempt from such affronts.
With the PCR technique, numerous organisms have also been identified from ocular fluids and implicated in ocular inflammation including HTLV-1, rubella, Epstein-Barr virus, HHV-6, human parechovirus, dengue and chikungunya virus [ 69- 71].
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