Sentence examples for human degeneration from inspiring English sources

Static compression decreases disc cell numbers, simulating human degeneration [ 23- 27].

For this reason, injury-mediated degeneration is a powerful technique to study the basic science of disc degeneration and to develop therapeutic strategies to regenerate tissue according to the comparable endpoints of both injury-initiated degeneration and human degeneration.

On the other hand, the primary criticism of disc injury models is that the rapid advancement of degeneration does not replicate changes seen in human degeneration, which tends to develop over the course of many years.

Since the hallmark catabolic processes such as matrix breakdown and decreased cellular biosynthesis during human degeneration are mediated by a number of cytokines, including IL-1β and TNF-α [ 9- 14], we chose to mimic the degenerative state by treating organ-cultured discs with a cocktail containing both these cytokines.

In humans, degeneration of the auditory nerve (AN) in the inner ear secondary to hair cell loss is an irreversible process, which eventually reduces residual hearing in any hearing impaired patient [ 1, 2].

If SIRT1 is one of the constitutive inducers of human IVD degeneration, grade 4 degeneration discs should show stronger SIRT1 mRNA expression than lower grade discs.

CD dogs are considered a suitable animal model for human IVD degeneration because of their spontaneous IVD degeneration, and therefore studies investigating cell-, growth factor-, and/or gene therapy-based regenerative therapies with this model provide information relevant to both human and canine patients.

Accordingly, the main features of human IVD degeneration were found in rabbit IVD with mucous degeneration, granular changes as well as cracks and tears being formed as a function of age.

Moreover, the similarity with the previously identified expression patterns in human disc degeneration suggests that our model accurately recapitulates natural disc degeneration.

Our data therefore uncover a physiological role for ADAM9, reveal what we believe may be a novel causative pathway for human retinal degeneration, and highlight a potentially overlooked pathological feature of retinal degenerations, including CRD and AMD.

The preliminary clinical diagnoses for the affected SWHDs suggested that the disease was comparable with human cone degeneration, hence the inclusion of CNGB3, CNGA3 and GNAT2, which are associated primarily with cone degeneration.