Sentence examples for human constant from inspiring English sources
There are four major antibody types used as therapeutics: fully non-human (most commonly mouse), chimeric (non-human variable region, human constant) [ 8], humanized (human and non-human variable region sequence, human constant) [ 9, 10], and fully human [ 4].
This resulted in the advent of chimeric antibodies with murine variable regions (VL and Vh) and human constant domains (CH2 and CH3) as well as humanized and fully human antibodies.
From the Trojan war to the invasion of Iraq, the march of folly has been a human constant.
Two chimeric monoclonal antibodies (MoAbs) were designed with variable parts of the mouse antibodies W6/32 and F3.3, and the human constant parts C-gamma1 and C-kappa.
By linking them to human constant or Fc regions, expression of complete human immunoglobulin molecules was achieved in insect cells by infection with recombinant baculovirus.
Rituximab is a genetically engineered chimeric IgG1 kappa immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences.
One longs for Josephson to isolate the factors, to separate the universal human constants here, like the messianic drive of physicists, from the particular dictates of the Soviet system, with its penchant for standardization and megaprojects and the small role it allowed for public input or market analysis.
Rituximab (IDEC-C2B8; MabThera®, Roche, Basel, Switzerland; Rituxan®, Biogen Idec, Inc., Cambridge, MA, USA and Genentech, Inc., South San Francisco, CA, USA) is an IgG1, chimeric monoclonal antibody (mAb) containing murine light-and heavy-chain variable-region sequences and human constant-region sequences.
"She offered me what I had never found in my life with humans: constant, single-hearted, incorruptible, uncritical devotion, which it is in the nature of dogs to offer".
The pTS-mIgG and pTS-mIgK plasmids were constructed by replacing the human IgG constant gene of pTS-hIgG with the PmlI/NotI-digested mouse IgG or IgK constant region, respectively.
G1Δnab is a mutant human IgG1 constant region with a lower ability to interact with FcγR than the natural IgG constant regions.
