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As expected, Krt18, ERα, and PgR were preferentially expressed in mature luminal cells in both mouse and human, consistent with immunostaining of freshly sorted cells [ 7, 12].
In the comparison between mouse and human, the CGI was conserved in the expected position, but Peg13 sequence was not highly conserved between mouse and human, consistent with the rapid sequence evolution of noncoding genes (fig. 1).
By bioinformatic analyses, we identified the Xenopus orthologue of human heparanase 2. The protein is extensively conserved between frog, mouse and human, consistent with conserved functions between diverse species.
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LBNP has been demonstrated to produce physiologic changes in humans consistent with hemorrhage.
The new study suggests that all the cognitive abilities needed to move to cooking food must already have existed in the common ancestor of chimpanzees and humans, consistent with the inferences based on study of molars.
Thus, the data indicated that the results of animal studies could be used to predict a no effect level for acute CNS depression in humans, consistent with the framework described above.
Two of them alter amino acids that are conserved from yeast to humans, consistent with their considerable impact on MMR.
Conversely, the accumulated clinical experience of masitinib (>485 patients exposed) has revealed no evidence of cardiotoxicity in humans; consistent with its known low cardiac risk pharmacological profile [14].
These data indicate that the element lies in a region of low polymorphism in humans, consistent with the possibility of a recent selective sweep.
In particular, the hypothesis was tested that oral consumption of curcumin could produce liver tissue concentrations in humans consistent with levels shown to exert pharmacological action in vitro.
The International Agency for Research on Cancer recently classified PCE as probably carcinogenic to humans (Group 2A) on the basis of sufficient evidence in animals and limited evidence in humans, consistent with the U.S. EPA's conclusion (Guha et al. 2012).
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