With respect to human tumors, concordance has been found between gene expression profiles from fresh-frozen and FFPE colonic epithelial cells isolated by laser capture microdissection [ 3].
In addition, in twin studies of FASD in humans, greater concordance of phenotype was observed in identical twin pairs compared with fraternal twin pairs, indicating either a genetic effect on the susceptibility to the negative effects of DAE or effects of placental development on the amount of ethanol fetuses are exposed to (Warren and Li 2005).
Similar to the mouse results, a direct comparison of the genes which were altered between the fetal vs. adult livers and the adult pancreas vs. the adult liver also showed extensive overlap in humans, including concordance of the overlapping genes in direction of change and intensity of the differences.
Our HBWoE approach calls attention to this and recognizes that the weight-of-evidence evaluation should evaluate these subsidiary conclusions about the plausibility of human mechanisms and their concordance or lack of concordance with mechanisms in animals.
The high degree of concordance with human QTL demonstrates usefulness of our approach in humans.
Similarly, Mendelian-inheritance error checking of the custoMendelian-inheritance error errors, checking with 2.38% human errofs identheied by concordance checking.
To elucidate the concordance of human papillomavirus (HPV) genotypes between the mother and her newborn and to identify risk factors for the vertical transmission of HPV.
The results of chronic rodent carcinogenicity bioassays demonstrate strong concordance with human cancer responses, and the results of 2-year bioassays are accepted by both American and international regulatory agencies as providing adequate assessments of the potential carcinogenic activity of drugs and chemicals.
Despite this, the human results are in concordance with multiple animal studies [5, 49, 54 57, 61, 62] that support the clinical data [50] that P-APRV may be used to reduce the incidence of acute respiratory distress syndrome (ARDS) more effectively than conventional LTV ventilation applied early or after the onset of ARDS.
Next we examined the concordance of human and murine gender biased genes in the kidney.
These points of concordance between human and model TOJ performance suggest that the brain indeed integrates across the full posterior probability distribution.
