Sentence examples for human checkpoint from inspiring English sources

Todd McDaniel tells the BBC: "We've got a human checkpoint".

Germline mutations in the human checkpoint gene, hCHK2, were first identified in 1999 in cases of Li–Fraumeni syndrome.

The phosphorylation networks we construct, centered on the human checkpoint kinase BUB1B (BubR1) and its yeast counterpart MAD3, offer a unique view of the spindle checkpoint that emphasizes biologically relevant phosphorylated forms, phosphorylation-state specific phosphorylation-state specifictionshiPPIs

Specifically, we build a phosphorylation network centered on the human checkpoint protein BUB1B and show that it provides a different, but complementary view of the spindle checkpoint from existing protein interaction network building tools.

Chen and Wang [ 36] recently reported that the stabilization of p53 conformation after heat shock is associated with its binding to Hsp90 protein and that the phosphorylation of p53 is dependent on the Ataxia-telangiectasia-mutated protein kinase (ATM -mediated ATM -mediated humactivationint 2 (ChK2) kinase.

Several years ago, we hypothesized that mutations in human spindle checkpoint genes could cause chromosomal instability in cancers11.

Li, Y. & Benezra, R. Identification of a human mitotic checkpoint gene: hsMAD2.

Here we demonstrate that ATR but not ATM phosphorylates the human Rad17 (hRad17) checkpoint protein on Ser 635) and Ser 645) in vitro.

In human cells, checkpoint responses can be divided into p53-dependent and p53-independent pathways, the latter being predominant in G2 phase of the cell cycle.

Jin, D. Y., Spencer, F. & Jeang, K. T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.

Cds1p (human Chk2p) checkpoint protein kinase-dependent phosphorylation of Yox1p promotes its dissociation from the MBF transcription factor.