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Paul Nurse's important work on the mechanics of human cell division - the work that won him the biggest prize in science and a call from the producer of Desert Island Discs - was initially conducted in the 1980s, but it has taken the Nobel people this long to acknowledge it.
Researchers have suspected for about 12 years that human cell division is regulated by structures called telomeres, specialized stretches of DNA located at the ends of the chromosomes.
Although de Lange notes that telomere shortening needs further investigation, she says there's now no doubt that telomeres play a critical role in limiting human cell division and that telomerase can reactivate the process.
We are currently using mitotic selection to obtain cells for the examination of subcellular localization of interesting proteins, and are searching for new regulators of the cell cycle, primarily those essential for progression into and beyond the G1 phase of the human cell division cycle.
Damage of the human cell division by lovastatin has been reported in a previous study [ 20].
As expected, these genes (MYBL2, PLK1, CDC2 and MCM genes) are also contained within our GPS (see Supplementary Table 2), reflecting the universal mechanisms that govern human cell division.
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The herpes simplex virus (HSV) host-cell factor HCF-1 is a key regulator of multiple steps in the human cell-division cycle.
A human stem cell division rate of once every four days and the parameter values in Table 1 approximate the epidemiology and the observed mutation frequencies of colorectal cancers.
As well as being important for cell division, human ORC has been implicated in Meier-Gorlin syndrome, a type of dwarfism.
Cellular senescence was initially described by Hayflick (46), as he pointed out that normal human fibroblasts undergo robust cell division in tissue culture, followed by a gradual decrease in PDL rate over time, until they cease to divide altogether.
While budding yeast (Saccharomyces cerevisiae) have usually been used in these types of studies, fission yeast (Schizosaccharomyces pombe) maintain many more of the basic cancer-relevant cellular processes present in human cells (e.g., cell division, DNA replication, and heterochromatin assembly), making fission yeast a potentially much more general model for mode of action studies.
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