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This toxin is life threatening for millions of people and growing menace to society since causing human botulism.
Among the seven serotypes, BoNT/A and B are commonly associated with human botulism, but the former causes more severe consequences than the latter [5].
Four of the seven serotypes, A, B, E, and F, cause human botulism with the vast majority of cases due to serotypes A and B [5].
Thus, the cTA12 antibody may possibly be considered as a promising candidate of therapeutic tool and could be combined with other mAbs for the treatment of human botulism.
BoNT/B is the most frequent cause of human botulism in Europe (including Italy) and the second leading cause of botulism in North America [13], [14].
While A, B, E, and F have been definitively linked to human botulism, G has been implicated in 7 cases of sudden unexpected deaths [12], [13], and C, D are typically associated with farming/wildlife outbreaks.
Similar(29)
Or imagine if corn or wheat was infected, either with an agent that kills it, or with a disease deadly to humans, such as botulism.
In particular, biogas plants are discussed to contribute to the spreading of Escherichia coli infections in humans or chronic botulism in cattle caused by Clostridium botulinum.
TA12 is also more potent than the human botulinum immune globulins used to treat infant botulism [30].
Seven antigenically distinct botulinum neurotoxins (serotypes A to G) are known, but primarily serotypes A, B, E, and F have been reported to cause botulism in humans.
Through this mechanism of action, they can cause the flaccid paralysis of botulism in humans exposed through foodborne intoxication or intestinal and wound toxemias, thus representing a serious pathogenic and biodefense threat.
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CEO of Professional Science Editing for Scientists @ prosciediting.com