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The data for normal expression (Human Body Index project) were downloaded as GSE7307 and GSE3526 [34].
Samples from the publicly available human body index were clustered to assess whether similar tissue samples have similar patterns in TSR scores.
We selected 621 samples, representing over 90 distinct tissue types from the publicly available human body index dataset from the Gene Expression Omnibus (Accession number: GSE7307).
This dataset consisted of normal adult human tissue samples from the human body index compendium study (GSE7307), hES cells, hiPS cells, and fibroblast lines (GSE9709 and GSE9832) [3], [29].
This consisted of human tissues measured in the Human Body Index Transcriptional.
Array data of normal endometrium controls were from a Human body index dataset in GEO (GSE7307).
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In this research, the human body index-transcriptional profiling of tissue-specific gene expression data set was downloaded from the gene expression omnibus (GEO) for GSE 7307 series [ 27] to predict disease genes.
Affymetrix data for a set of 87 different normal human tissue types (the 'human body index' set) representing a total of 504 tissue samples were retrieved from the NCBI website.
Affymetrix data for a set of 87 different normal human tissue types (the 'human body index' set) representing a total of 504 tissue samples were retrieved from public gene expression omnibus (GEO) data sets on the National Center for Biotechnology Information (NCBI) website (Barrett et al., 2005, 2007).
Of these eight genes, NUDT3 could be a candidate gene for the SSC7 locus, as NUDT3 variants have been associated with changes in human body mass index values [ 33] and height [ 34].
Illustrating this point, a recent meta-analysis of human body mass index (BMI) GWAS, including 250 000 subjects, identified 32 associated single nucleotide polymorphisms (SNPs), accounting for only 1.45% of variation in BMI (11).
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