In a recent work by Leidner et al. [ 28], the authors highlighted for the first time the widespread inconsistency across circulating miRNA studies, cautioning the scientific community about the huge variety of methodological parameters impairing circulating miRNA evaluation.
This has mostly led to huge variations in terms of methodological approach to design these models, type of data used and eventually results interpretations and policies design.
The methodological challenges are huge [ 2], but still quite some health impacts are currently attributed directly or indirectly to climate change [ 2, 3].
In the absence of guidelines for pharmacogenetic studies, we also incorporated recommendations from the HuGENet (Human Genome Epidemiology Network) HuGE Review Handbook (13) and prior methodological papers (14).
These studies mostly of low methodological quality have revealed huge disparities in the prevalence of CKD across SSA regions depending on the definition, method for assessing glomerular filtration rate (GFR) and targeted population [ 4, 9– 14].
methodologies - which survey major methodological approaches in a given domain.
This work focuses on the architectural, methodological and technological aspect of handling huge amounts of data.
However, it is a huge and complex database and there are some important methodological and technical difficulties for using it due to its volume and architecture.
However, due to methodological and interpretational challenges, inadequate facilities, or huge costs, several of the current available imaging techniques are still not in routine use.
To study sediment-generation processes in the huge catchment and compare the different erosion patterns obtained by different methodological approaches, high-resolution petrographic and heavy-mineral analyses were performed on sands from the trunk river and its major tributaries.
