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The excision of introns coupled to exon ligation to form mRNA molecules is performed by the spliceosome, a huge macromolecular machinery composed of five snRNPs (U1, U2, U4/U6 and U5 snRNAs associated with proteins) and many additional splicing factors.
It is a huge macromolecular protein exceeding a molecular weight of 2 MDa.
It requires much fewer computational resources compared to the conventional method, so that the applications to huge macromolecular structures such as ribosomes and virus capsids (13– 17) are possible.
Given the structural complexity and extraordinary transport capabilities of NPCs, it is quite surprising that these huge macromolecular assemblies of 40 60 MDa are only composed of ∼30 different proteins.
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DNA damage is repaired by huge multisubunit macromolecular complexes of dynamic composition and conformation.
Reversible addition fragmentation chain transfer (RAFT) polymerization has made a huge impact in macromolecular design.
Advanced crosslinked polymeric materials based on poly(ionic liquid)s, also named supported ionic liquid-like phases (SILLPs) combine some unique characteristics of ionic liquids with the general property profile of macromolecular architectures, and present huge potential in energy-/environment-/catalysis-oriented applications, in the development of "smart" dispersants and stabilizers, etc.
PILs combine the unique properties of ionic liquids with the flexibility and properties of macromolecular architectures and provide novel properties and functions that are of huge potential in a multitude of applications, including solid ionic conductor, powerful dispersant and stabilizer, absorbent, precursor for carbon materials, porous polymers, etc.
The huge IC lacunae of granulocytes observed under normotonic conditions may serve as a storage compartment and be tightly filled by macromolecular complexes and nuclear bodies, whose nature was not analyzed in the present investigation.
Huge, huge.
At Cambridge, Jean Olwen Thomas, professor of macromolecular biochemistry, becomes a dame in recognition of her work in biochemistry.
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