Actually, evolution can only produce a genome devoid of "junk" if and only if the effective population size is huge and the deleterious effects of increasing genome size are considerable (Lynch 2007).
The strong mutational constraint on the protein in the high-temperature environment (36°) in conjunction with a relatively high relative growth rate of the wild type results in the most clearly different DFE among the six environments, with a huge number of deleterious mutants, and almost no mutants better than wild-type average.
"As a cartilage biologist, I feel that if you're putting your joint under that huge load, then it's deleterious".
Intermicrobial signalling agents exert their function at extremely tiny concentrations, so that the exposure to huge concentrations of signals has deleterious effects not only on bacterial cells, but also on the entire wiring system of microbial ecosystems.
A. This is a a huge issue, a major problem that has a profound and deleterious impact on the district.
Distinguishing cancer-associated deleterious systemic changes from insignificant changes is a huge challenge.
However, since the GABA accumulation observed in these transgenic plants was also associated with a huge decrease of glutamate pool, authors did not conclude to a possible deleterious effect of GABA [ 48].
It has been proposed that accumulation of multiple mildly deleterious rare, but not monogenic, gene variants in individual human genomes has a huge impact on the genetic basis for complex diseases contributing with a large relative risk at the individual level [ 78].
Unexpectedly, mitochondrial genes, despite low effective population sizes and no recombination, seem to eliminate slightly deleterious mutations more effectively than orthologous genes in obligate intracellular and even free-living bacteria which have huge population sizes and nonzero recombination level.
"It had a deleterious impact".
