Roche for instance, in May ceased development of what it had hoped would be a huge-selling cardiovascular drug after the compound, called dalcetrapib, did not succeed in a late-stage clinical trial.
Among the factors involved in the huge increase of cardiovascular risk occurring in diabetes mellitus, a pivotal role is played by a reduced synthesis and action of nitric oxide (NO) [ 1], a substance exerting a major role in vascular biology by a wide array of antihypertensive and antiatherogenic properties [ 2– 4].
Boston Scientific paid a huge amount for the cardiovascular device manufacturer Guidant, despite revelations during the bidding process of quality problems and cover-ups.
The global burden of disease and mortality due to cardiovascular diseases is huge, and in this respect the United Arab Emirates (UAE) is no exception [ 1].
Our results indicate that the substitution of saturated fat for polyunsaturated fat in the diet decreases total cholesterol levels (204.09 versus 194.15 PP = 0.005) and LDL levels (121.02 versus 107.85; P = 0.0001) that could provide huge benefits to decrease the cardiovascular risk as many studies indicate [ 5, 21].
Although huge advances in the treatment of cardiovascular diseases have been made during the last decades, the morbidity and mortality associated with heart diseases are still too high [ 1].
The increasing incidence of non-communicable diseases (NCDs) including diabetes and cardiovascular diseases, places a huge burden on Egypt's healthcare resources and about 41%% of all deaths in Egypt are from NCDs [ 5].
As reported above, the impact of postprandial hyperglycemia on CVD is still a matter of debate, and perhaps we will obtain an answer from the Acarbose Cardiovascular Evaluation (ACE), a huge trial performed in China.
Being able to understand very early risk indicators or risk factors for later cardiovascular disease would be a huge benefit.
Despite increasing investigation in the area of cardiovascular instability in preterm infants, huge gaps in knowledge remain.
