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Many functional hubs themselves do not have large numbers of direct physical interactions with other proteins.
The lack of differential expression for most of the hubs themselves argues that the observed differential connectivity patterns are not primarily due to primary alterations of hub gene expression, but rather due to more subtle changes in expression of numerous genes interacting with these hubs.
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Whereas "authorities" are Web pages that are "linked by many others," hubs "link themselves to many pages".
Although they were identified as being involved in the infection process of H. parasuis, most of the hub immunogenes themselves had no significant expression changes in the differential expression test.
While the mRNA levels of the genes encoding for the hub proteins themselves are not affected by EGF, we can detect strong changes in many of the genes directly connecting to them and a high interconnectivity among regulated genes pertaining to each hub's own network.
So the question these cities, along with any others looking to grow their technology hubs, must ask themselves is, "How can we tap into Silicon Valley's resources to improve our economy?" Cultivating the next Apple, Google or Facebook can create thousands of technology-related jobs, which would have a huge impact on any local economy in a short time.
From the connectivity point of view, we may therefore identify roughly the first 200 300 nodes in these networks as hubs, since by themselves they form a highly fragmented subgraph.
The other foreign capitals speak for themselves as hubs of war, conflict or escalating nuclear tensions.
Charleston, S.C., for example, is among the regional hubs that are promoting themselves to businesses within a five-hour drive.
That is not just because sports leagues abroad face the same issue, but also because the pirates themselves, the hubs of the peer-to-peer networks that facilitate the illicit streaming of live games, are mostly outside the United States.
Increasingly, as lifestyle-focused corporate social networks assert themselves as hubs for identity in the modern world, there's no doubt that more of these types of media plays will crop up.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com