The regulatory network is designed to co-regulate processes, and its evolutionary history must include a bias towards hub-regulation of individual processes.
Therefore, constitutive phosphorylation at Thr171 in the SLBP L-motif is an important "hub" for regulation of the SLBP histone mRNA complex.
We observed this by higher counts of the disruption motif in tumors which reflects the disruption of co-regulation of the hub, but maintained regulation between the neighbors of the hubs (motif B in Figure 4).
Both processes are concordantly regulated by the same enzyme, PYK, a new hub in the regulation of these fundamental metabolic processes.
The αC-helix plays a crucial role in integrating the hydrophobic residues, making it a hub for allosteric regulation of kinase activity and the active conformation.
Therefore, the NMDAR is a major hub for the regulation of PSD structure and composition and its activation appears to be essential for triggering disassembly of the PSD; however, our study demonstrates that divergent downstream signalling pathways regulate the demise of each PSD component.
Generally, transcription factors tend to be the hub node in regulation network and under stronger functional constraints.
While PHYTOCHROME-INTERACTING FACTOR4 (PIF4) has been identified as a major ambient temperature signaling hub, its upstream regulation seems complex and is poorly understood.
The proteasome is a hub for the regulation of many cellular signaling pathways, and proteasome inhibition therefore appears to induce apoptosis through a number of mechanisms.
An association of ABC and PS45 with membranes has been described before in other cell lines (Maher et al., 2009; Maher et al., 2010) and might reflect the existence of a specific hub for their regulation.
LAT deficiency also leads to augmented TCR-ITAM and ZAP-70 phosphorylation (Salek et al, 2013), further supporting the role of LAT as a hub for signal regulation (Acuto et al, 2008; Mingueneau et al, 2009; Shen et al, 2010).
