We also speculated that, in addition to their being hubs, P bodies may contribute also to the transport of mRNAs to specific locations within the cytoplasm.
We observed that proteins with a higher number of interactions are significantly more likely to be disease hubs (P < 10-8 as calculated by a one-way ANOVA).
Specifically, nine brain disorders had lesions that were significantly more likely to be located in hubs (P < 0.05, permutation test), including schizophrenia and Alzheimer's disease.
More intriguingly, network hubs are significantly enriched in structural proteins (38/92 hubs, P < 0.05, Bootstrap resampling) and these structural proteins, which accounted for 60/173 proteins, were significantly enriched in promiscuous domains (31/60, P < 0.005, Bootstrap resampling).
In the first stage, there are some candidate nodes to establish hub facilities (Fig. 1a) and the model determines location of hubs (p-hubs) from candidate nodes (Fig. 1b).
Moran's I bivariate analysis indicated a positive correlation between USN and hub distance (p = 0.03), area of coverage (p = 0.02), and facility transport time (p = 0.03).
The most important features of problem are (a) ordinary nodes must be connected to hubs, (b) each ordinary node is allowed to connect only into one hub, (c) P hubs are established and (d) to cover an O/D pair, length of established path must be smaller than the specified covering radius.
As it may not be ideal to assign the demand nodes to their nearest hub, the p-HMP relaxes this constraint.
There was a 7.6-fold overrepresentation of disease-associated proteins among candidates (hypergeometric P-value=2.1e-07 P-value=2.1e-07 P-value=2.1e-07old in all Multis (hypergeometric P-value=9.3e-19) and hubut(hypergeonlyric P-value=0.0003), respectively.
The p-hub center location problem aims to locate p hubs and allocate other nodes to these hub nodes in order to minimize the maximal travel time.
