It can be developed in a sprint or like a video game, posted on a Web page or printed as a work of paper art, a hub of social interaction that becomes a book club or a rare escape through which a reader can power down the outside world.
This analysis placed Myc as the hub of the interaction network and prompted us to perform further analysis on its biological significance.
Overall, this invokes two important concepts: first, that the functional partners of candidate therapeutic hub genes may represent additional targets based on shared genetic interactions, and second, that the DNA replication fork is a hub of SL interactions with CIN cancer genes.
In its role as a hub of protein protein interactions that mediate and regulate DNA synthesis, the B subunit participates in multiple simultaneous interactions with different polymerase subunits.
While Ctf4 act as a hub of protein interactions within the replisome progression complex (Miles and Formosa 1992; Zhou and Wang 2004; Gambus et al. 2006, 2009; Tanaka et al. 2009), little is known about the molecular function of Chl1.
One of the most highly connected replication fork proteins is Ctf4, which appears to function as a scaffold during DNA replication and repair, acting as a hub of protein−protein interactions (Im et al. 2009; Mimura et al. 2010; Zhu et al. 2007).
There were also two categorical variables: physical interaction status (not hub, intermediate number of interactions, party hub, and date hub) (Han et al. 2004; Ekman et al. 2006) and the presence of transmembrane segments (not predicted, predicted by only one study, and predicted by two studies) (Persson and Argos 1994; Krogh et al. 2001).
Discrimination of date- and party-hubs of protein interaction networks, i.e. proteins sequentially or simultaneously interacting with a large number of neighbors, is a rather difficult task [32] [37].
We applied two measures: network fragmentation and betweenness centrality to identify genes that play the role of so called communication hubs (mediators of interactions between other, more peripheral genes).
