The SMART Center will serve as an intellectual hub for interactions between MIT and global researchers in Singapore at exciting frontier areas of science and technology.
Our results indicate the presence of several HCMV proteins that serve as "hubs" for interactions with numerous protein partners, thereby may function as an organizing center for connecting viral proteins in the mature virion and for recruiting other virion proteins.
In all cases, phosphorylation creates a binding site or "hub" for protein protein interactions.
Other studies have shown selective killing by PARP inhibition of cells from diverse tumor types bearing mutations in ATM, MRE11A, BRCA2, or the EWS-FLI1 translocation, suggesting that PARP is a bona fide hub for genetic interactions with cancer genes (Brenner et al. 2012; Bryant et al. 2005; Farmer et al. 2005; Vilar et al. 2011; Williamson et al. 2010).
Subsequent IPA-based analyses of the associated network functions further identified the insulin protein complex as the hub molecule for interactions among the miRNAs of this class (discussed later).
Strikingly, we find that the pYDDV motif selectively attracts proteins that take part in TCR proximal signaling which hints towards a function of this ADAP motif as a central hub for phosphorylation-dependent interactions.
The insula, especially the anterior insula, has been considered as an integral hub for mediating dynamic interactions between other large-scale brain networks, such as the default mode network, salient network, and central executive network.
In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating neuronal extension and guidance, as well as synaptic organisation.
Our results confirm members of the DNA replication fork as hubs for genetic interactions with many cancer gene orthologs and suggest other potential hub pathways.
The potential interactome for SH2 domains indicates many cases of potential overlap in binding, resulting in pTyr sites that may act as hubs for multiple interactions or serve distinct binding functions in cases where the SH2 complement varies in different cells.
These features suggest that the activity of the animal Atg13-Atg101 subcomplex is regulated and that it is an interaction hub for multiple partners.
