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The average hub difference (AvgPCC) off correlation (Pearson's correlation co-efficient (PCC)) values between the disease and control groups was calculated as follows: (3) A v g P C C = ∑ i = 1 n (D i - C i ) n where D i and C i represent the correlations of a hub and its interactors for the disease and control groups respectively and n the number of i interactors for a given hub.
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In the entire data set of 40 samples with complete genomic data, it was noted via manual analysis of scatterplots of primary hub genes that differences in the 8 YSTs relative to the other samples dominated the signal.
The hubs frequently correspond to pathway regulators, and in many cases a functional difference between hub genes in two conditions reflects the global change underlying the different phenotypes.
Now, however, the race is on to save the industry and Cape Town is emerging as a design capital and manufacturing hub with a refreshing difference – it has safe workplaces and a desire to share the stories of its garment workers.
Taking the square root of these values allows us to calculate that the average growth rate difference between hub disruption strains was ~11.7% compared to ~0.7% between random disruption strains.
Hecate considers itself "a new hub of respect for differences, critical thinking and change".
Mr. Harris said electricity users would benefit from the energy transfers, and the hub would reduce large differences in price among the grids.
This study used highly connected hub neurons to quantify differences in fragility between structure at 2 scales.
However, comparison of this brain tissue microglia-enriched module to the pure microglia expression profiles, showed substantial differences in hub genes.
As both connectivity in protein-protein interaction networks and differences in hub behavior correlate with rate of evolution for artifactual reasons (Batada, Hurst, et al. 2006; Batada, Reguly, et al. 2006; Batada et al. 2007), we shall not consider them here.
We summarize the connection degree (i.e. the number of connections) of each node of Figure 6 in the supplemental material [see Additional file 4] and compile a list of regulators with connection degree ≧ 8 (see Table 2) to identify perturbed hub proteins that induce differences between inflammatory and normal conditions.
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